HYPERHOMOCYSTEINEMIA: A SILENT HASSLE FOR HUMAN BEINGS, ALLIED COMPLICATIONS AND PRAGMATIC STRATEGIESAbstract
Hyperhomocysteinemia is a metabolic catastrophe characterized by an elevated level of homocysteine above 15 mmol/L in blood. It is an established risk factor for cardiovascular anomalies. The illness has also crucial impact on other organs and tissues of body. Its morbid effects have been seen during many chronic conditions. It is also considered as a metabolic crunch during gestation as well as geriatric conditions. Increased homocysteine has also been seen to play a critical role and key factor in development of many health issues including stroke, cancer, and neurodegenerative diseases. Although, it is an autosomal recessively inherited defect, but can also be developed during intake of vitamin deficient high protein diet. This illness causes many ill effects on our vital organs and becomes a risk factor for several health complications such as venous thrombosis and vascular damage. The existing treatment includes vitamin B12, B6, and folic acid, but based on the mechanism of this disease methyl donor substance (natural product or synthetic moiety) may also be utilized in order to alleviate the illness.
J. K. Gupta *, S. Mujwar, K. K. Varshney and M. Varshney
Institute of Pharmaceutical Research, GLA University Mathura, Uttar Pradesh, India.
10 March 2019
14 June 2019
17 November 2019
01 December 2019