HYPOGLYCEMIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF PEPEROMEA PELLUCIDA (L.) HBK (PIPERACEAE)Abstract
The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 to 8.1 mM ±SEM) i.e., 68.44% in 300mg/kg ethyl acetate extract as a 7 days hypoglycemic treatment. On 120 minutes OGTT test, reduction of blood glucose level was also significant. In 300mg/kg extract blood glucose level reduced from (20.53mM to 7.69 ±SEM) 62.64% was observed. Analgesic treatment was observed carefully and mentionable activities were evaluated. Percentage of inhibition was 58.16 with the number of writhing 11.8±SEM in 300mg/kg inhibition was observed with 6.8 ±SEM writhing. P. pellucida has significant anti-inflammatory effect after 4 hr with 3.47± SEM. The present study indicates significant hypoglycemic, analgesic and anti-inflammatory effects of P. pellucida. The present investigation established the pharmacological evidence to support the folklore claim and that of the plant has antidiabetic, analgesic and anti-inflammatory activity.
Hasib Sheikh*, Shotabdi Sikder , Sagar Kumar Paul , A.M. Rashedul Hasan , Md. Mofizur Rahaman and Sangita Paul Kundu
Lecturer, Department of Pharmacy, Bangladesh Institute of Medical Science (BIMS), N/23, Nurjahan Road, Mohammadpur Dhaka-1207, Bangladesh
19 July, 2012
21 November, 2012
29 December, 2012
01 January, 2013