HYPOLIPEDEMIC EFFECT OF CYNODON DACTYLON ON HISTOPATHOLOGICAL STUDY AND DNA FRAGMENTATION ANALYSIS IN EXPERIMENTALLY INDUCED HYPERCHOLESTEREMIC RATSAbstract
Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Cynodon dactylon (Bermuda grass) on histopathological study and DNA fragmentation analysis in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, hypercholesterolemia rats (4% Cholesterol＋1% cholic acid), Cynodon dactylon treatment in hypercholesteremic rats and Cynodon dactylon alone treated rats. Results of DNA fragmentation was found to be greater in High cholesterol diet fed groups. Lesser fragmentation was found in high cholesterol diet + Cynodon dactylon treated group when compared to the high cholesterol diet group. Cynodon dactylon alone treated group is comparably similar to that of normal group (lesser fragmentation). Histopathological study of thoracic aorta of Cynodon dactylon treated group shows decrease in atherogenicity compared to untreated high cholesterol diet fed rats. The data demonstrated that Cynodon dactylon formulation was associated with hypolipidemic effects on the experimentally induced hypercholesteremic rats.
C. Selva Kumar * and R. Kalaivani
Department of biochemistry, Sri Manakula Vinayagar Medical College & Hospital, Madagadipet, Puducherry-605107, India
30 June, 2011
16 October, 2011
28 October, 2011
01 November, 2011