IMPACT OF CELL SENESCENCE ON AGE – RELATED NEURODEGENERATIVE DISORDERS: THE MECHANISM TO THERAPY- A REVIEWAbstract
Aging is a natural phenomenon; it is a well-known fact that everyone is aging as time passes. A major contributor to this process is cell senescence. Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. It was first observed by Hayflick. Senescent cells show a distinctive feature called Senescent associated secretory phenotypes (SASP) which includes increased expression of p16 and Beta-galactosidase can be used as a marker for senescent cells. Senescent cells are involved in exacerbating various kinds of age-related disorders such as diabetes, obesity, cardiovascular diseases, neurodegenerative diseases, etc. This review is focused on the major factors responsible for cell senescence, its related pathways, and the role of cell senescence in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The paper also throws light on how cell senescence can be used to treat cancer known as therapy-induced senescence and various strategies to treat age-related pathologies by senotherapy in which senescent cells are targeted.
N. Jadon, N. Sabharwal and S. Bhattacharya *
Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.
20 August 2018
05 December 2018
20 January 2019
01 May 2019