IMPORTANCE OF SR-B1 RECEPTOR IN CARCINOGENESIS AND TREATMENT: A REVIEWAbstract
Scavenger receptor class B member 1 also known as SR-B1 is a receptor that in human is encoded by the SCARB1 gene. SR-B1 functions as a receptor for high density lipoprotein. SR-B1 receptor is mostly found in liver and is best known for its role in facilitating the uptake of cholesteryl ester from HDL in liver. This movement of cholesterol is known as reverse cholesterol transport. Cancerous cells generally have high requirement for cholesterol as they are rapidly dividing cells. HDL acts as carrier for cholesteryl esters and triglycerides. The high affinity of cancer cells for HDL has made HDL useful as carrier for delivering anti-cancer drugs into cancerous cells. So synthetic rHDL particles are designed as carrier for anti-cancer drug owning to their structural features, biocompatibility and targeting capability via receptor mediated mechanism due to which cytotoxic effect of cancer chemotherapeutic drugs on healthy organs can be significantly diminished by employing rHDL as carrier. Drugs incorporated into rHDL were 2.5-23 times cytotoxic to cancer cell than the free drugs.
Y. S. Yadav*, A. K. Vishwakarma, V. K. Yadav, R. K. Yadav and P. Yadav
Department of Pharmacy, Prasad Institute of Technology, Dr. A.P.J. Abdul Kalam Technical University, Jaunpur, Uttar Pradesh, India.
22 September, 2016
20 November, 2016
01 February, 2017
01 April, 2017