IMPROVEMENT OF DISSOLUTION RATE OF POORLY SOLUBLE ALPRAZOLAM BY SOLID DISPERSIONAbstract
Dissolution rate enhancement of alprazolam, an anti-anxiety drug, was done by preparing solid dispersions by solvent evaporation method .Polyethylene glycol 6000 and Polyvinyl pyrrolidone k-30 were selected as carriers. Drug: Polymer ratios were taken as 1:1,1:2and1:4 for both the polymers for the preparation of solid dispersions. Tablets were prepared from solid dispersions and also from physical mixtures by direct compression. Dissolution rates and drug releases of solid dispersions or their tablets were found more than those of corresponding physical mixtures or their tablets.
Niranjan Kumar Manna* and Laxmikanta Roul
Department of Pharmaceutics, College of Pharmaceutical Sciences, Mahuda, Berhampur - 760002.Ganjam, (Orissa) India
14 August, 2010
12 November, 2010
23 December, 2010