IMPROVING SOLUBILITY OF CURCUMIN IN AQUEOUS SYSTEM BY THE SELF-ASSEMBLY OF HYPERBRANCHED POLY(AMIDE-ESTER) AND CURCUMINAbstract
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Fluorescence quenching ananlysis reveal that the fluorescence quenching of curcumin is due to the formation of ground state complex between curcumin and hyperbranched poly(amide-ester) and the binding constant was 3.98×105L·mol-1. The other analysis also can prove the formation of complex between curcumin and HBPAE. The solubility of curcumin in aqueous solution was greatly increased more than 1000-fold at the presence of hyperbranched poly(amide-ester).
Sujuan Wang *, Tongtong Li, Xixi Peng and Xinwu Ba *
College of Chemistry and Environmental Science, Hebei University, Baoding, P. R. China.
26 September, 2016
13 November, 2016
01 December, 2016
01 April, 2017