IN-SILICO DOCKING ANALYSIS OF PHYTOCHEMICALS FROM VERBASCUM PHLOMOIDES L. AS AN ANTIVIRAL AGENTS AGAINST HERPES SIMPLEX VIRUS TYPE I AND TYPE IIAbstract
Almost 85% of the world population is infected with the Herpes Simplex Virus (HSV). Herpes simplex virus infections have been described in the medical literature for centuries, yet the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatments. Additionally, the details of the inhibition of Herpes virus type 1 are still not fully understood. The present study was undertaken to evaluate the antiviral property of selected phytochemicals from Verbascum phlomoides L. through their interaction with the Herpes simplex virus. Depending on the non-covalent interaction and best docking score it was concluded that these phytochemicals may be useful for treatment against Herpes infection and can act as inhibitors to Herpesviral protein receptor. Also using phytochemicals as a medium of medication may reduce the cost dependent factor and can be widely used as medicinal purposes to treat several chronic and dreadful diseases.
M. A. Bhuvad and L. R. Samant *
Molecular Genetics Research Lab, B. J. Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India.
23 June 2018
30 August 2018
06 September 2018
01 March 2019