IN-SITU BUFFERED FORMULATION: AN EFFECTIVE APPROACH FOR ACID LABILE DRUGAbstract
“Acid labile drug” means a drug that is easily destroyed in acidic environment, Stomach is the main site for drug absorption mainly by oral rout. The pH of the stomach is acidic so the absorption of acid labile drugs through stomach is difficult. For this resign the drugs should be formulated as enteric coated or may be administered through parenteral rout. These approaches are effective but they increase the cost of the dosage form. So for making the acid labile drug effective in acidic environment one of the best approach is in-situ buffer formulation. These are the formulation containg agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. This article covers the possible approaches for buffer formulation, formulations could be possible, method of preparation and evaluation of in-situ buffer formulation. The articles the examples of agents can be used as buffers.
Preeti Khulbe *, Birendra Shrivastava, Pankaj Sharma and Ajay Kumar Tiwari
Jaipur National University, Jagatpura Jaipur, Rajasthan, India
19 July, 2016
13 September, 2016
16 November, 2016
01 January, 2017