IN-VITRO ANTI-PROLIFERATIVE ASSAY AND CELL VIABILITY ACTIVITY OF BAICALEIN USING BREAST CANCER CELL LINEAbstract
Objective: The flavonoid baicalein, is historically used as an herbal medicine by the Chinese, which produces a wide range of pharmaceutical effects, among which is the potent anticancer activity which has raised a great conflict of interest in the recent years. This study aims to verify the anti-proliferative and the cell viability effects of baicalein on metastasis of MCF-7 human breast cancer cell lines by in-vitro, to investigate the related mechanisms. Methods: MTT assay was used to investigate the anti-proliferative activity of baicalein using MCF-7 cell lines and trypan blue assay method were used to examine the effects of baicalein on cell viability on MCF-7 cell lines. Results: The in-vitro cytotoxicity activity studies were proved that cancer cell lines were inhibited significantly with the increasing of sample concentration.
V. Jayashree* and N. Thenmozhi
School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
30 June, 2017
18 December, 2017
27 January, 2018
01 April, 2018