IN-VITRO EVALUATION OF EFFECT OF HYDROALCOHOLIC MEDIA ON DRUG RELEASE FROM SUSTAINED RELEASE FORMULATIONAbstract
In the recent development, worldwide consumption of alcohol has shot up in the past decade as a part of lavish and Gen next lifestyle changes. There have been innumerable instances of people consuming alcoholic beverages and drugs at the same time. Hence in our study, Diclofenac and Metformin were selected as representatives of highly prescribed and overused drugs. Hence, the present study was planned to design dissolution media and to study drug release of different brands of the same drugs using newly designed media. Various hydroalcoholic media were prepared. Optimization of new, chemically defined dissolution medium was done by comparison of release profiles of Metformin HCl and from Diclo IR 1, Diclo DR 2 and Diclo SR1, Diclo SR2 tablets of Diclofenac Na. The Metformin IR and Diclofenac IR tablets showed faster release in strong beer than mild beer and rum. It can be concluded that both the strength and volume play an essential role in the release pattern of IR formulations. The SR formulations of Metformin HCl and Diclofenac Na showed that the release was similar in 40% alcohol as well as rum. However, the release was somewhat slower in strong and mild beer indicating the effect of strength of alcoholic beverage. Thus, the phenomenon of higher and faster release pattern of the drug in alcoholic beverages is directly proportional to the concentration of the alcohol. Higher the alcoholic concentration, greater is the disruption of the formulation and faster the release pattern.
A. Joshi *, A. Shaikh, S. Ingale and A. Gothoskar
Department of Pharmaceutical Chemistry, SCES’s Indira College of Pharmacy, Pune, Maharashtra, India.
13 December 2017
11 September 2018
25 September 2018
01 April 2019