IN-VITRO EVALUATION OF ORODISPERSSIBLE FILM OF ALLIUM SATIVUM LINN.Abstract
The treatment of cancer up to the saving of life of cancer patient is rare miracle. Cancer is deadly disorder (some cancers are diseases caused by viruses) if diagnosed in second or third stage leads to death, hence it is better to prevent it. The present study emphasizes on prevention of cancer rather than cure. Extraction of garlic was carried out by using maceration process. The liquid extract was concentrated under vacuum at 25 °C. Concentrated extract was exposed to UV light and packed in a suitable container for use in formulation development. Orodisperssible film formulation was developed by solvent casting method. In-vitro activity was evaluated on different cancer cell lines like human colon cancer cell line (COLO 205) and human prostate cancer cell line (PC-3). As compared to standard drug, Adriamycin (Doxorubicin) of allopathic origin, orodisperssible film formulation containing hydro-alcoholic garlic extract shows comparable tumor suppressive activity. Hence, orodisperssible film formulation containing stabilized garlic extract will find its place in nutraceutical market. To warrant further tumor suppressive activity shall be done in-vivo to determine safety, efficacy, mechanism of action of Allium sativum Linn., anti-carcinogenic effect etc.
D. R. Pawar * and S. R. Butle
School of Pharmacy, “Dnyanteerth”, Vishnupuri, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.
28 August, 2018
20 October, 2018
29 October, 2018
01 November, 2018