IN VITRO STUDY OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY WATER SOLUBLE DRUG SPIRONOLACTONEAbstract
The main objective of study was to formulate SEDDS of Spironolactone in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of Spironolactone using oils (Arachise oil, Oleic Acid, Castor oil, Soyabean Oil, Neobee M5, Migloyol, Capmul), surfactants (Tween-80, Cremophor RH40,Cremophor EL) and adsorbents (Aerosil-200,Avicel PH101,Lactose, Dextrose, Mannitol and Talc). In case of SEEDS of Spironolactone, the release rates of all oils were very rapid in Avicel PH101(above 82%) because it has the best flow property among the other absorbents. It Self Emulsifying Drug Delivery System observed that the release pattern from Arachis oil (92.95%), Oleic acid (90.21%) and Castor oil (97.54%) were better in comparison to other oils. Besides, it can be comprehend that the release rate of the three oils were very rapid in Tween-80(above 85%) because it has the best emulsifying property than Cremophor RH40 and Cremophor EL. Besides the solubility of Spironolactone in various oils was determined to identify the oil phase of SEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. The formulation was found to show a significant improvement in terms of the drug release with complete release of drug within 60 minutes. Thus, Self microemulsifying formulation of Spironolactone was successfully developed.
Irin Dewan*, Mahjabeen Gaji, Mohammad Shahriar and S.M. Ashraful Islam
Assistant Professor, Department of Pharmacy, University of Asia Pacific, Road # 5 A, House # 73, Dhanmondi, Dhaka-1209, Bangladesh
19 November, 2011
24 December, 2011
23 February, 2012