IN-VIVO ANTIOXIDANT AND ANTIHYPERLIPIDEMIC ACTIVITY OF SYZYGIUM CERASOIDEUM EXTRACTS IN RATSAbstract
Antioxidant and antihyperlipidemic activities of the extracts of Syzygium cerasoideum were investigated by studying their in-vivo effects on triton and cholesterol induced hyperlipidemia. Highest antioxidant activity was exhibited by methanolic extract followed by chloroform extract of S. cerasoideum. In triton induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease in the levels of TC, TG, LDL-C, VLDL-C particularly treatment with CESC at the dose of 200 mg/kg b.w resulted in significant decrease in levels of TC (67.60%), TG (47.89%), LDL-C (85.80%) and VLDL-C (47.89%) whereas HDL-C levels are significant to standard. In cholesterol induced hyperlipidemic model, the groups treated with the extracts of S. cerasoideum and pitavastatin demonstrated a significant decrease with the CESC and MESC at low doses in the serum levels TC (68.68%), TG (60.22%), LDL-C (85.44%), VLDL-C (70.71%) besides an increase in serum HDL-C (62.26%) levels when compared to cholesterol-induced hyperlipidemic control group. The treated groups of S. cerasoideum caused a significant decrease in the levels of SOD, CAT and GSH activities of MESC at the doses of 400 mg/kg/day and 10 mg/kg/day compared to the cholesterol-induced hyperlipidemic control group. It was observed from the histopathological findings that the rats fed with S. cerasoideum extracts showed a decrease in moderate microvesicular changes caused by cholesterol feedings. Results suggest that the methanolic followed by chloroform extracts of S. cerasoideum containing polyphenols and flavanols possess significant antioxidant and antihyperlipidemic activities.
S. Sadik *, K. M. Geetha and Vasia
Department of Pharmacology 1, Oxbridge College of Pharmacy, Bengaluru, Karnataka, India.
10 October 2018
18 January 2019
30 January 2019
01 June 2019