INFLUENCE OF PIOGLITAZONE ON IMMUNOMODULATORY ACTIVITY OF AZATHIOPRINE IN RODENT MODELSAbstract
The present study was designed to investigate the antioxidant and immunomodulatory activity of Azathioprine-Pioglitazone combination therapy to check whether it has added on benefit over monotherapy with Azathioprine or Pioglitazone in rodent models. The test drugs in combination showed better inhibition of free radicals in both H2O2 radical scavenging assay and nitric oxide scavenging assay than individual counterparts revealing its potential antioxidant activity. The combination showed its significant effect on both cell-mediated and humoral immunity to suppress stimulated immune responses in delayed-type hypersensitivity test, carbon clearance test, and nitro blue tetrazolium test. The study proved that Pioglitazone enhances the antioxidant and immunomodulatory activity of Azathioprine indicating the possible synergistic interaction between them.
P. V. Babu *, V. Soundarya and M. G. Raju
Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.
22 November 2018
03 March 2019
08 March 2019
01 August 2019