IODOMETRIC METHOD FOR THE DETERMINATION OF MEZLOCILLINAbstract
Kinetics and stoichiometry S-oxidation reaction of sodium monohydrate Mezlocillin (Mezl) using potassium hydrogen peroxomonosulfate in aqueous solutions using iodometric titration were studied. Baypen®-powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). A new iodometric method for the quantitative determination of sodium monohydrate Mezl in Baypen® preparation using potassium hydrogen peroxomonosulfate (KHSO5) as analytical reagent was proposed. Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone®) of “extra pure” qualification was used as the oxidant. At pH 1-4 for 1 mole of penicillin, 1 mole of KHSO5 is consumed, the quantitative interaction is achieved within a time of more than 1 min (observation time). The results were obtained by the recommended procedure for seven replicate titrations of mixtures containing the three species at various concentrations. RSD = 2.01%, δ = (+ 0.51) %. It can be seen that Piperacillin can be determined successively with good accuracy and reproducibility. The new procedure was developed, and the ability of quantitative determination of penicillin in pharmaceutical preparation Baypen® by an iodometric method using potassium hydrogen peroxomonosulfate (KHSO5) as analytical reagent was shown.
S. P. Karpova *, T. V. Krutskikh, O. O. Mozgova, and A. A. Krutskikh
Department of Physical and Colloid Chemistry, National University of Pharmacy, Kharkiv, Ukraine.
30 August 2018
29 October 2018
31 October 2018
01 May 2019