ISOLATION AND EVALUATION OF STARCH FROM MUSA PARADISIACA LINN. AS A BINDER IN TABLETAbstract
A hydrophilic polysaccharide become isolated from green fruit of Musa paradisiaca L. by the usage of wet milling procedure and distilled water extraction the use of sodium sulphite solution, accompanied by way of maceration, centrifugation and sedimentation. The isolated polysaccharides became characterised for physicochemical properties, viscosity and flow behaviour, scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and XRD study. Diverse concentrations of isolated polysaccharide had been studied for binding property towards Maize starch in traditional tablet formulation. In vivo toxicity study detected secure nature of the isolated polysaccharide. Standard, the outcomes of the present study indicated that isolated polysaccharide is resembles to starch and not useful for frozen products. Polysaccharide is shows Pseudoplastic nature with thixotropic behaviour and smooth surface and elongated oval shape granules seen on SEM Micrograph. Form experiment the optimized concentration banana starch as a binder is 5 to 6 %w/w for solid dosage forms. The outcomes of the study suggested that isolated polysaccharides is promising binding agent as a pharmaceutical excipient in drug delivery system.
S. Sandhan*, N. Thombre and S. Aher
MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India
11 January, 2017
17 March, 2017
22 March, 2017
01 August, 2017