KRILL OIL: THE MOST POWERFUL OMEGA 3 KNOWN ON EARTHAbstract
A diet rich in marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve overall health and wellbeing. An association between consumption of fish and seafood and beneficial effects on a variety of health outcomes has been reported in epidemiologic studies and clinical trials. These effects are mainly attributed to the omega-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) abundant in fish and seafood, and in particular to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Reports on health benefits have led to increased demand for products containing marine n-3 PUFAs. Since fish is a restricted resource, there is growing interest in exploiting alternative sources of marine n-3 PUFAs. Antarctic krill (Euphausia superba) is a rich source of n-3 PUFAs. Most of the health benefits provided by frequent seafood consumption come from adequate uptake of omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, and antioxidants. Optimal n-3/n-6 PUFAs ratios allow efficient inflammatory responses that prevent the initiation and progression of many inflammatory disorders. Moreover, interesting in-vivo and clinical studies with the marine antioxidant carotenoid astaxanthin (present in krill oil) have shown promising results against free radical activity in different diseases. This review presents the state-of-the-art applications of krill oil as a rich source of n-3/n-6 PUFAs and astaxanthin against diseases associated with exacerbated oxidative stress in human body.
A. Sati * and P. Bhatt
Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, Uttarakhand, India.
29 October, 2017
17 February, 2018
accepted, 06 March
01 July, 2018