MICROWAVE-ASSISTED SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR ANTI-INFLAMMATORY ACTIVITYAbstract
A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds N-(3,5-bis(trifluoromethyl)benzyl)-4-((2-(6-methyl-2-(p-tolyl)imidazo [1,2-a] pyridine-3-yl) acetamido) methyl) benzamide and N- (4-methoxybenzyl)-4- ((2-(6-methyl-2-(p-tolyl) imidazo [1,2-a]pyridin-3-yl) acetamido) methyl) benzamide are possessing high anti-inflammatory activity against standard drug Aspirin. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory activity.
P. Budumuru *, S. Golagani and B. Pushpanjali
Department of Chemistry, Institute of Science, GITAM Deemed To Be University, Visakhapatnam, Andhra Pradesh, India.
25 June 2018
01 September 2018
06 September 2018
01 March 2019