MOLYBDENUM BLUE METHOD FOR THE SPECTROPHOTOMETRIC DETERMINATION OF LEVETIRACETAM- CALCIUM CHANNEL MODULATORAbstract
A simple, accurate, precise and easy spectrophotometric method for the determination of levetiracetam in pharmaceutical formulations using molybdenum blue method was developed by the authors. Aqueous solution of the drug sample on reaction with ammonium molybdate solution and hydrazine sulphate solution on heating for 5 minutes at a temperature of 60 0 C gave a clear, stable and intense blue colored molybdenum blue complex. This molybdenum blue showed a λmax at 823nm. Beer’s law was found to be obeyed in the range 0.02-0.08mg/ml. correlation coefficient was found to be 0.998. Molar abosrptivity was found to be 240.2 lit/mole/cm. LOD and LOQ was found to be 0.12 mg/ml and 0.37mg/ml respectively. The method is important in view of the fact that the excess dosage causes clinical problems and optimum dosage has to be fixed in the use of the drug.
G. V. S. R. Pavan Kumar *, K. Srinivasa Rao, Yerra Bharath and M. Komal Avinash
Department of Chemistry, MVGR College of Engineering, Vijayramnagar campus, Chintalavalasa, Vizianagaarm - 535002, Andhra Pradesh, India
19 September, 2016
25 November, 2016
28 November, 2016
01 April, 2017