NANOCRYSTAL SUSPENSION OF POORLY WATER SOLUBLE ANTIBACTERIAL DRUG BY HIGH PRESSURE HOMOGENIZATION TECHNIQUE USING FULL FACTORIAL DESIGNAbstract
Cefixime trihydrate belongs to third generation cephalosporin having poor water solubility. In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing enhanced solubility and stability with reduced particle size and thus improving the bioavailability potential. Nanocrystal suspensions were prepared by high pressure homogenization technique and evaluated for particle size, polydispersity index, zeta potential, and drug release. 23 factorial design was used for the formulation designing purpose. Particles of average size 143.5nm having PDI of 0.269 were produced. Zeta potential was found to be -36.6mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and scanning electron microscopy studies. The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nanocrystal formulation.
R. Bhaskar* and P. H. Patil
Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
22 April, 2017
26 July, 2017
31 July, 2017
01 January, 2018