PATHOPHYSIOLOGICAL STATUS OF SERUM ANTIOXIDANT, MACRO-MINERALS AND TRACE ELEMENTS IN PATIENTS WITH METABOLIC SYNDROME IN BANGLADESHAbstract
This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro – minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spectrophotometry method, while Macro-minerals and trace elements were determined under coordination of two methods these was flame atomic absorption spectrometry (FAAS) and graphite furnace. This study found that Vitamin C is lowering significantly (p < 0.05) in patients with metabolic syndrome while compared with control subjects. Analysis of serum trace elements (Zn, Fe) and macro minerals (Ca, Na, K) explored low serum concentrations in examined patients significantly either than control group (P < 0.05). Pearson’s correlation analysis revealed negative correlation between blood glucose and Fe, Triglyceride and Zn level were found statistically significant. On the basis of our present study it can be asserted that depletion of Vitamin C, Zn, Fe, Ca, K and Na levels is strongly associated with the metabolic syndrome pathogenesis.
M. S. Rahman, K. Hasan, Md. S. Hussain, Md. S. Millat, N. Sen, M. S. Islam*, Md. S. Sarwar, W. Noor, A. Kar, S.M.N. Uddin and K. Yokota
Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
05 June, 2017
23 November, 2017
06 January, 2018
01 March, 2018