PHARMACOGNOSTIC EVALUATION AND ANTIMICROBIAL STUDIES ON MORINGA OLEIFERA LAM. (MORINGACEAE)Abstract
The pharmacognostic evaluation, anatomy and antimicrobial potentials of the leaf, stem and root of Moringa oleifera Lam were evaluated. Powdered extracts obtained from the various plant organs were used for the analytical standardization. The methanolic plant extracts were assayed for antimicrobial activities using the Agar well diffusion method. This was compared with standard antibiotics, Gentamicin and ketoconazole. The Minimum Inhibitory Concentrations (MIC) of the methanolic plant extracts against the sensitive microorganisms was determined via the turbidity method. The results of the analytical standardization of the powdered leaf, stem and root of Moringa oleifera were found to be within pharmacopoeial standards. The results of the anatomical studies showed normal tissue distribution with distinctive features and structures, which could be instrumental for delimiting other closely related species. The phytochemical analysis revealed varying concentrations of alkaloids, tannins, flavonoids, saponins, steroids, terpenoids, resins, proteins and carbohydrates. The plants extracts exhibited antibacterial activities against all test bacteria. The stem extract particularly was better effective against Salmonella typhi than Standard antibiotic Gentamicin, with an MIC of 10.89 mg/ml and 13.88 mg/ml respectively.
CEC Ugwoke *, KA Eze, KM Tchimene and SPG Anze
Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka, Nigeria
19 July, 2016
05 September, 2016
26 September, 2016
01 January, 2017