PHARMACOLOGICAL EVALUATION OF SOME NOVEL THIENO 1, 2, 3-TRIAZINES-4-ONES FOR ITS ANALGESIC ACTIVITYAbstract
The analgesic activity was assessed using hot plate method, formalin induced paw licking test, acetic acid induced writhing test. Preliminary investigations were carried out with water, DMSO and chloroform for solubility. For analgesic activity 1, 2, 3- triazine-4-ones series of compounds CP1, CP2, CP3 showed significant increase in jumping time of mice in hot plate method at only higher dose level (50 mg/kg). In acetic acid induced writhing test in mice at higher dose levels CP1, CP2, CP3, (50 mg/kg) significantly inhibited the number of writhing in mice. 1, 2, 3-triazine-4-ones series of compounds CP1, CP2, CP3 at (25 and 50 mg/kg) significantly inhibited formalin induced paw licking at both early and late phases. These results indicate that compound possessed both central and peripheral analgesic actions. It was found that the CP1, CP2, CP3 compounds shown good analgesic activity in formalin induced paw licking test at both dose levels (25 and 50 mg/kg) but in other two model hot plate method and acetic acid induced writhing model; shown good analgesic activity at higher dose level only (50 mg/kg).
P. Raghav, R. Srinath and P. Deep*
Amity Institute of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.
09 July, 2017
01 November, 2017
17 November, 2017
01 April, 2018