PREPARATION OF A TRADITIONAL POLY HERBAL PRODUCT AND STABILITY ASSESSMENT OF THE DOSAGE FORMAbstract
“Soda” is one of the humors in the body which should be in normal level for being healthy. If “soda” increases in the body, some undesirable symptoms appear. In order to eliminate the excess “soda”, at first it should be maturated. There are different formulations in Iranian traditional medicine references as “Monzig-e-soda” which is a way of maturation of black bile. In one of the references, the aqueous extract of Cordia mixa, Glycyrrhiza glabra, Adiantum cappilus-veneris, Foeniculum vulgare, Fumaria spp, Lavandula angustifolia, Echium amoenum, Melissa officinalis and Ziziphus jujuba is prepared as decoction. In the present investigation, the capsule form of the plants was prepared and its stability was assessed. The mentioned species were mixed in ratio of 2.4:1.5:1:1:1:1:1:1:2, respectively and extracted with water (1:10) in 90 °C, 2h. The aqueous extract was dried and packaged in capsules 500 mg. In order to assess the stability of capsules, they were divided into two groups: group 1 were placed in 30 °C and room humidity for 12 months (long- term stability) and group 2 were put in 40 °C and 75% humidity for 6 months (accelerated stability). Sampling was performed every 2 months and total phenolic compounds, mucilage content and microbial levels were determined in each sample. The results showed no significant changes in total phenolics and mucilage contents of the capsules during accelerated tests. Microbial tests were in agreements with references. For estimating expiration date for the product by using Y=2X formula, two years stability could be predicted.
H. R. M. Esfahani, H. Hajimehdipoor*, N. Dorri, L. Ara, B. Eslami, S. Fahimi and S. M. H. Kojoori
Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
30 May, 2017
19 August, 2017
26 January, 2018
01 March, 2018