REACTIVE OXYGEN SPECIES (ROS) ARE BOON OR BANEAbstract
Reactive oxygen species (ROS) are inevitable by-products of cellular respiration. These are highly reactive chemical species derived from molecular oxygen (O2). These include the superoxide (O2−) and hydroxyl (HO−) free radicals as well as non-radical molecules such as hydrogen peroxide (H2O2). These act as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Redox regulation or controlled ROS generation is the net effect of a subtle balance between ROS generation and neutralization or utilization by cellular antioxidant systems. The most deleterious effect of ROS is “oxidative stress”. Oxidative stress plays a major part in the development of chronic and degenerative ailments such as cancer, arthritis, aging, autoimmune disorders, cardiovascular and neurodegenerative diseases. Several mechanism exists to counteract oxidative stress. This review provides a detailed overview of the influence of ROS on human pathophysiology and novel therapeutic strategies followed to treat ROS mediated diseases or disorders.
Seema Tripathy * and Prafulla Kumar Mohanty
Department of Zoology, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India.
09 July, 2016
07 September, 2016
13 September, 2016
01 January, 2017