RECOVERY OF LIVER DAMAGED BY CCl4 UNDER TREATMENT BY CONJUGATE OF DRUG XYMEDON WITH L-ASCORBIC ACIDAbstract
The aim of the study is to investigate the capacity of pyrimidine derivatives like the active ingredient of Xymedon (I) and its derivative, salt-like conjugate with L–ascorbic acid (II) to stimulate liver recovery when damaged by toxic hepatitis. The study was done on out breed white rats. The liver damage was induced by carbon tetrachloride (injected 50% oil solution subcutaneously, once per day, 2-4 times, dose of solution 2 ml/kg). Tested compounds ((I), (II), Thiotriasolinum) were administered orally in the dose 20 mg/kg within 5 days. The new derivative (II) possesses pronounced hepatoprotective properties. It was established the obvious advantages of (II) in comparison with both Xymedon and Thiotriasolinum. Application of (II) improves of general medical condition of the animals (increase in the survival rate up to 100 %), the structure and morphology of their liver (reducing the symptoms of destructive, degenerative and irreversible changes to hepatocytes) and biochemical markers of cytolysis, synthetic and metabolic liver ability in blood (recovery in the levels of alanine-aminotransferase, aspartate-aminotransferase, γ-glutamyl-transpeptidase, total protein, cholesterol, alkaline phosphatase).
A. B. Vyshtakalyuk *, N. G. Nazarov, V. E. Semenov, I. V. Galyametdinova, R. G. K. Diabankana, A. G. Porfiriev and V. V. Zobov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Subdivision of the Federal State Budgetary Institution of Science, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
10 January, 2018
03 April, 2018
13 May, 2018
01 October, 2018