RESVERATROL, A POTENTIAL RADIOPROTECTIVE AGENT: A MINI REVIEWAbstract
It is well known ionizing radiations produce deleterious effects on humans. In spite of research efforts for the past several years, today we do not have a radio protective agent that meets all the prerequisites like produces no cumulative and irreversible toxicity, offers effective long term protection, possess a shelf life of 2-5 years and can be easily administered. In recent years, attention has been turned to phytochemicals due to their antioxidant properties. This review focuses on the radio protective potential of resveratrol [trans-3, 5, 4’- trihydroxystilbene], a phytoconstituent, mainly found in Vitis vinifera. In particular, it aims to highlight the detailed studies, both in vitro and in vivo, that have been carried out on the radio protective capability of resveratrol. It also focuses on the different possible mechanisms through which resveratrol acts in response to ionizing radiations. Previous studies show both positive and negative aspects of resveratrol on radioprotection. But a thorough analysis including earlier studies and our own preliminary studies clearly support that resveratrol is an attractive and potential candidate and can be developed into radio protective agent.
D. Thekkekkara, B. Duraiswamy and M. J. Nanjan*
PG Studies and Research / TIFAC CORE, J.S.S. College of Pharmacy, (Off Campus, JSS University, Mysore), Ootacamund, The Nilgiris, Tamil Nadu, India.
13 February, 2017
24 April, 2017
27 May, 2017
01 September, 2017