REVIEW ON THE FIXED DOSE COMBINATION DRUGS AND THEIR INCOMPATIBILITIESAbstract
Incompatibility is an undesirable reaction that occurs between drugs, excipients, or with container. This may be therapeutic, chemical and physical incompatibility. Fixed dose combination provides challenge in product development due to incompatibility of two drugs. So severe degradation of drug in presence of each other. Formulation and stability difficulties arise with incompatible combination. It involves interaction between two or more substances (drug-drug, drug-excipients, drug-excipients-drug interactions) which leads to change in colour, odour, taste, viscosity, and morphology. There are various approaches to overcome incompatibility. Among which the bilayer tablet is one of the suitable approach and increasing attention from a variety of industries for various reasons viz. Therapeutic and marketing attendance with the great physical, chemical and microbial stability. The purpose of this review is to study the physical incompatibility between fixed dose combinations, to find remedies that overcome the problems in designing formulation and to select best optimised approach to reduce incompatibility issue in fixed dose combinations.
Anand D. Savkare* and Rekha K. Wakhare
Department of Pharmaceutics, MVP Samaj’s college of Pharmacy Nashik, Maharashtra, India
02 January, 2017
07 March, 2017
22 March, 2017
01 July, 2017