ROLE OF INTERFERONS IN CLINICAL PRACTICEAbstract
Interferons were the first cytokines to be used therapeutically as naturally derived and as recombinant forms in humans. Their broad biological activity has resulted in clinical benefits in diseases ranging from infectious (such as viral hepatitis), autoimmune (in particular multiple sclerosis) to neoplastic (lymphomas and carcinomas). Since Interferons enhance the immune system in many ways, they are used for many diseases that involve the immune system. For example; Interferon alfa-2a (Roferon-A) is FDA-approved to treat hairy cell leukemia, AIDS-related Kaposi’s sarcoma, and chronic myelogenous leukemia. Interferon alfa-2b is approved for the treatment of hairy cell leukemia, malignant melanoma, condylomata acuminata, AIDS-related Kaposi’s sarcoma chronic hepatitis C, and chronic hepatitis B. Ribavirin combined with interferon alfa-2b, interferon alfacon-1 (Infergen), pegylated interferon alfa-2b, or pegylated interferon alpha-2a, all are approved for the treatment of chronic hepatitis C. Interferon beta-1b (Betaseron) and interferon beta-1a (Avonex) are approved for the treatment of multiple sclerosis. Interferon alfa-n3 (Alferon-N) is approved for the treatment of genital and perianal warts caused by human papillomavirus (HPV). Interferon gamma-1B (Actimmune) is approved for the treatment of chronic granulomatous disease and severe malignant osteopetrosis.
Sadiya Khwaja, H.H. Siddiqui and Tarique Mahmood*
Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow-226026, Uttar Pradesh, India
13 November, 2013
22 February, 2014
09 March, 2014