ROLE OF LIQUID MEMBRANE HYPOTHESIS IN THE MECHANISM OF ACTION OF ERTAPENEMAbstract
The role of liquid membrane hypothesis has been studied in the mechanism of action of Ertapenem. In the present study transport of selected permeants (glucose, p-amino benzoic acid and ions like magnesium, ammonium, phosphate, calcium, sodium, potassium and chloride) through liquid membrane generated by Ertapenem in series with supporting membrane has been studied. The results indicate that the liquid membrane generated by Ertapenem inhibit the transport of various essential bio-molecules and permeants into the cell. The data indicate that modification in permeability of different permeants in the presence of the liquid membrane is likely to play significant role in the biological actions of Ertapenem. It seems that the formation of liquid membrane by Ertapenem may also contribute for the bactericidal activity of the drug, in addition to its conventionally established mechanism i.e. inhibition of cell wall synthesis.
Abhay K. Jain *, Manish Srivastava and Sharad K. Gupta
Department of Chemistry, D. D. U. Gorakhpur University, Gorakhpur - 273009, Uttar Pradesh, India
29 January, 2014
27 March, 2014
26 April, 2014
01 July, 2014