SCOPE AND EVALUATION OF SAPODILLA PECTIN IN PHARMACEUTICAL SOLID AND LIQUID ORALS WITH ESPECIAL REFERENCE TO ITS EFFECT ON VARIOUS PHYSICO-MECHANICAL PROPERTIES UPON BOTH SOLID AND LIQUID DOSAGE FORMAbstract
The aim of this study was to understand and study the role and effect of different concentration of sapodilla pectin as a binding agent in tablet formulations and also its on the effect on physical evaluation of suspension. For this purpose two model drugs paracetamol and ibuprofen were selected and granules were made by wet granulation using different concentration of pectin. The tablets were first tested for its micromeritics properties of the granules. After the formulation of the desired tablets, they were compressed and were tested for quality. While for suspension kaolin and sapodilla pectin were used in combination to form antidiarrheal preparation and was evaluated physicaly. It was found that the concentration of added pectin has an influence on both the micrometric properties of granules as well as on the dissolution profile of formulated tablets. Both the tablets showed increasing hardness and lowering of dissolution rate with the addition of increased amount of pectin. However the best formulation for paracetamol was F4 and F5 with 40 and 50 mg of pectin respectively while for ibuprofen R1 it was with 50mg of pectin concentration. The antidiarrheal preparation also exhibited similar results in terms of its evaluation as suspension. The study clearly showed that pectin from sapodilla peel can be used effectively in the formulation of paracetamol and ibuprofen tablets as well as in antidiarrheal suspension.
N.H. Siddiqui*, I. Azhar, S. A. Khaliq and Z. A. Mahmood
Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Pakistan.
26 April, 2017
10 July, 2017
25 July, 2017
01 January, 2018