SOFT CHEMICAL SYNTHESIS OF Ag DOPED ZnO NANOPARTICLES: ANTIMICROBIAL ACTIVITY AND IN VIVO ACUTE NANOTOXICOLOGICAL IMPACT ON SWISS ALBINO MICEAbstract
In this research work Zn1-xAgxO1-δ (where x = 0.05, 0.10, 0.15 and 0.20) nano powders were synthesized via simple soft chemical method using corresponding metal nitrates and alkali precipitant. Sodium hydroxide was used as a precipitant during the synthesis. The prepared samples were characterized using X-ray diffraction, FTIR spectroscopy, particle size analysis, SEM, EDAX analysis and TEM. The antimicrobial activity of the silver doped zinc oxide nanoparticles were studied against both Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Escherichia coli and Klebsiella pneumoniae) bacteria by agar well diffusion method. Considering the better antimicrobial properties obtained with Zn0.80Ag0.20O1-δ, these materials were subjected for in vivo acute oral nanotoxicological studies in Swiss Albino mice. The histopathological changes in livers and kidneys of Swiss Albino mice due to the oral ingestion of the above material (Zn0.80Ag0.20O1-δ) at different dosage levels on day 14 administration have shown the LD50 as greater than 2000 mg/kg body weight.
P. Suresh Kumar and A. Samson Nesaraj *
Department of Science and Humanities, (Chemistry), Karunya University, Karunya Nagar, Coimbatore, Tamil Nadu, India.
21 December, 2016
25 February, 2017
16 May, 2017
01 July, 2017