SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEMAbstract
Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles in the nanometer size range, which are dispersed in water or in an aqueous surfactant solution. SLN technology represents a promising new approach to deliver hydrophilic as well as lipophilic drugs. Due to their unique size dependant properly, lipid nanoparticles offer to devlop the new therapeutics. Method: The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for several levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site-specific drug delivery and hence have attracted the wide attention of researchers. Conclusion: The present review article focus on overview about the potential advantages, disadvantages, the excipients and all the different methods involved in their production methodology, Characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases. Special attention is given to models of drug incorporation in SLN and the release pattern of SLN.
I. D. Raut*, R. C. Doijad and S. K. Mohite
Rajarambapu College of Pharmacy, Kasegaon, Walwa, Sangli, Maharashtra, India.
13 June, 2017
25 October, 2017
06 January, 2018
01 March, 2018