SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS BY SOLID DISPERSIONAbstract
Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extruding method, spray drying technology, use of surfactant, electro static spinning method and super critical fluid technology. This paper also highlights the potential applications and limitations of these approaches in solid dispersions.
A. K. Chaturvedi and Amita Verma*
Department of Pharmaceutical Chemistry, Christian school of Pharmacy, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India
11 July, 2011
15 October, 2011
08 December, 2011
01 January, 2012