SPECTROPHOTOMETRIC ANALYSIS OF BOVINE SERUM ALBUMIN IN PRESENCE OF 1-(4-AMINOPHENYL)-3-PHENYLPROP-2-EN-1-ONESAbstract
Proteins, which are soluble under normal physiological conditions, sometimes form insoluble aggregates with serious medical implications. Bovine serum albumin (BSA), a structural analogue of human serum albumin. Bovine Serum Albumin (BSA) has been used as a carrier, and stabilizing agent, for insoluble fatty acids. The chemistry of chalcone has been recognized as a significant field of study. An interesting feature of chalcones is that they serve as starting materials for the synthesis of various heterocyclic compounds such as pyrimidines, pyrazolines, flavones, flavonols, flavanones, aurones and benzoylcoumarones as well as certain compounds like deoxybenzoins and hydantions which are of some therapeutic importance. A series of chalcones was synthesized by the Claisen-Schmidt condensation and the structures of 1-(4-aminophenyl)-3-phenylprop-2-en-1-ones were established with the help of IR and NMR study, then their effect was observed on bovine serum albumin. We have found that the synthesized chalcones interacted with bovine serum albumin and produce a great effect on their presence.
S. Garg, M. Singh and N. Raghav*
Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
13 January, 2014
03 March, 2014
05 April, 2014
01 July, 2014