STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUESAbstract
Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioavailability of poor water soluble drug Ibuprofen (BCS class II) using solid dispersion techniques. Ibuprofen solid dispersion was prepared by melt dispersion and solvent evaporation method. Drug-carrier physical mixtures were also prepared to compare the dissolution characteristics. Effects of different polymer i.e. Polyvinylpyrrolidone (PVP) k12, Poloxamer 407, PEG 4000 and PEG 6000 were studied for solid dispersion and physical mixture. Solid dispersions were investigated for Drug content, dissolution characteristics, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) analysis. All the solid dispersions showed better dissolution rate than physical mixtures. Solid dispersion of Ibuprofen containing PEG 6000 in combination with Poloxamer 407 at the ratio of 1:1:1 prepared by melt dispersion method showed faster and higher drug release. After the study of SEM, FTIR and DSC it was found that solid dispersion of Ibuprofen using Poloxamer 407 and PEG 6000 show satisfactory results. So, solid dispersion may be an effective technique to enhance dissolution rate of Ibuprofen.
Farhana Akter , Mukta Saha *, Johura Ansary , Arnab Debnath and Tahiatul Shams
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh
04 August, 2014
15 October, 2014
20 March, 2015
01 April, 2015