STUDY OF THE BINDING PROPERTIES OF GUM OBTAINED FROM CURCUMA AMADA ON MODEL DRUG PARACETAMOLAbstract
The aim of the present study is to evaluate the gum of Curcuma amada (mango ginger) as a tablet binder employing paracetamol as a model drug. Natural gums are economic, easily available and found useful as tablet binder. The physicochemical properties of a gum obtained from the rhizomes of Curcuma amada were characterized by Fourier transmittance infra red (FTIR) and Differential scanning colorimetry (DSC). Amada gum has a glass transition (Tg) temperature and melting peak at 94.3°C. Paracetamol tablets were prepared by wet granulation technique using amada gum as a tablet binder in the concentrations of 1%, 3%, 5%, 7% & 9% w/w and compared with standard binders. The prepared tablets were evaluated for tablet characteristics. The values of granules showed angle of repose good flow property. The hardness of the prepared tablets varies with binder concentration. The prepared tablets showed friability decrease with increases concentration and disintegration time increase with increase the binder concentration. In vitro drug release was also depending on binder concentration. Tablets with 1%and 5% w/w binder concentration showed optimum results than standard binders, thus conclusion was drawn that amada gum was found to be useful for the preparation of uncoated tablet dosage form.
N. Thakur *, P. Mittal, M. Goswami, R. Kaur, R. Bansal, M. Bansal, and V. Gupta
Chandigarh University, Gharuan, Mohali, Punjab, India
05 November, 2015
22 December, 2015
26 January, 2016
01 April, 2016