SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUIDAbstract
Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL) is reported. Anti-mycobacterial activity was performed using Mycobaterium smegmatis mc2 155, taking anacardic acid and ethambutol as standards. Of all the derivatives, 1-(2-hydroxy-6-pentadecyl)-N-(hydroxyethylaminoethyl) benzamide exhibited good anti-mycobacterial activity.
P. H. Kumar, V. Chandregowda and G. C. Reddy *
Vittal Mallya Scientific Research Foundation, Kanakapura Road, Bangalore, Karnataka, India.
09 February, 2018
11 April, 2018
13 May, 2018
01 October, 2018