SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-ARYLQUINOXALIN-2-AMINES BEARING BENZIMIDAZOLE DERIVATIVESAbstract
In the present study reports synthesis and development of 3-Chloro – N – ((5-chloro-1-tosyl-1H-benzo [d] imidazol – 2 – yl) methyl) – N arylquinoxalin-2-amines (5a-e) from 3-chloro-N-p-tolyl quinoxalin -2-amine (3) condensed with proporgyl bromide followed by adding 4-chloro-N1-tosylbenzene-1,2-diamine,by adopting simple procedure. All titled compounds were screened for their anti bacterial activity by using bacterial strins i.e Bacillus subtilis MTCC 441, Bacillus cereus ATCC 9372, E.coli ATCC 8739, and staphylococcus aureus ATCC 96, compounds 5c, and 4c, were proven highest zone of inhibition against bacterial strains and 5b and 4b were also proven moderate inhibition zone against above mentioned bacterial strains, and the structures of synthesized compounds were characterized by 1HNMR, 13CNMR And Mass spectral data.
G. Brahmeshwari *, P. Bhaskar and G. Kumaraswamy
Department of Chemistry, Kakatiya University, Warangal-506 009 (TS) - India
18 June, 2014
28 August, 2014
13 November, 2014
01 February, 2015