SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NOVEL BENZOTRIAZOLE DERIVATIVESAbstract
The vast investigations on the derivatives of 1, 2, 3-benzotriazole explore wide applicability for tagging and delivering a number of other heterocyclic nuclei with benzotriazole. In the present work, several derivatives of 1-(substituted)-5- [(N-benzotriazolo-methyl)-1, 3, 4-thiadiazolyl]- imidazole-2-thione have been synthesized and are evaluated for their anticonvulsant activity. The anticonvulsant activities of the synthesized derivatives were assessed by the maximal electroshock (MES) method. Electric shock (50 mA for 0.2 sec) was delivered with the help of a corneal electrode to induce hind limb tonic extension. The synthesized derivatives X2, X3 and X6 exhibited significant anticonvulsant effect against MES-induced seizure model as an indication for compounds which are effective in grand mal epilepsy
V. K. Singh *, P. Rishishwar, P. Bharadwaj and S. Alok
School of Pharmacy, Monad University, Panchsheel Nagar, Hapur, Uttar Pradesh, India.
02 August 2019
25 September 2019
25 December 2019
01 January 2020