SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL GLYCOSYL THIOCARBAMIDESAbstract
Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during recent years because of their potential pharmacological properties. Thiourea and their derivatives are important versatile reagent in organic synthesis and show strong antibacterial activity. Hence, in view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, we herein report the synthesis and antimicrobial studies of novel glycosyl thiocarbamides of amino tetrazole and aminopyrimidine. In present investigation, a series of novel protected glycosyl heterocycles were synthesized by reaction of glycosyl isothiocyanate with amino tetrazole and amino pyrimidine. The newly synthesized compounds were characterized on the basis of IR, 1HNMR and Mass spectral studies. Antimicrobial evaluation of the synthesized substituted thiocarbamides is also carried out. Antimicrobial activities of the synthesized compound were evaluated against bacteria E. aerogenesa, B. megaterian, S. marcescens, and M. luteus and Fungi A. niger and Penicillinium. All the newly synthesized glycosyl thiocarbamides exhibit promising antimicrobial activity.
A. D. Mangte *, S. J. Munshi and R. P. Nayak
P. G. Department of Chemistry, Shri P. M. Patel Institute of P. G. Studies & Research in Science, Anand, Gujarat, India.
24 January 2019
17 June 2019
24 September 2019
01 October 2019