SYNTHESIS AND CHARACTERIZATION OF NOBLE ANTICANCER DRUG OF CHITOSAN-5FU CONJUGATED FORMULATIONAbstract
Cancer is one of the emergings, and best-understood neoplasm’s from a genetic perspective, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not removing completely by current therapies. Chitosan is a polysaccharide β-linked D-glucosamine and N-acetyl-D-glucosamine were used as conjugate to 5Fluorouracil. 5FU is one of the most commonly used drugs to treat cancer. The present invention relates the 5 Fluorouracil drug react with chitosan and formed chitosan – 5FU conjugate and used as Nobel anticancer models in zebrafish as an alternative model. The conjugated drug may highly selective and sustain release of drug to treat effectively colon cancer models in zebrafish. 5-fluorouracil react with chloroacetic acid in presence of potassium hydroxide gives 5-fluorouracil acetic acid. 5-fluorouracil acetic acid reacts with chitosan and formed chitosan -5FU conjugate. Characterization of chitosan folic acid and chitosan 5FU studied details by FTIR and NMR and showed well structural conformation.
V. Surendra *, T. Haribabu, U. R. Sharma and P. M. Manjunatha
Acharya & B. M. Reddy College of Pharmacy, Bengaluru, Karnataka, India.
01 March 2019
08 November 2019
16 November 2019
01 December 2019