SYNTHESIS AND EVALUATION OF NOVEL THIOSEMICARBAZONE DERIVATIVES AS ANTICANCER AGENTSAbstract
: Thiosemicarbazobes are the compounds that possess wide range of biological activities. Presently the areas in which thiosemicarbazones receiving more attention is its use against cancer. Reports from the SAR studies confirms that the thiosemicarbazones with heterocyclic moiety shows carcinogenic potency. These are potent ribonucleotide reductase inhibitor. Adamantyl derivatives is also having interesting biological properties and most promising towards anticancer activity. The value of adamantyl group in drug design is multidimensional. A novel series of compounds of thiosemicarbazones were prepared by conjugating adamantyl group and using aromatic substitution. The various substitutions on thiosemicarbazones were reported as anti cancer activity and adamantyl group also show antiproliferative activity against some cell lines, so in present work 20 compounds were prepared on the basis of best results of QSAR studies and they were screened for anticancer activity using cell line studies. The results were compared with standard drug doxorubicin, 3 compounds show more inhibitory action than standard drug.
Niharika Gokhale * and Sanjay Jain
Department of Pharmaceutical Sciences, Gyan vihar University, Jaipur Rajasthan, India
28 August, 2014
16 February, 2015
25 March, 2015
01 April, 2015