SYNTHESIS & ANTI- MICROBIAL EVALUATION OF N-(2-(4-SUBSTITUTED PHENYL)-4-OXOTHIAZOLIDIN-3-YL) ISONICOTINAMIDE DERIVATIVESAbstract
A new series N-(2-(4-substituted Phenyl)-4-oxothiazolidin-3-yl)isonicotin- amide of derivatives were synthesized by the reaction of Schiff base (isoniazid and substituted benzaldehyde) with mercaptoacetic acid. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. The synthesized compounds showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.
S. Ramachandran, P. Shanmugapandiyan and C. N. Nalini
Asst. Prof. Department of Pharmaceutical Chemistry, Mohamed Sathak A. J. College of Pharmacy, Shollinganallur, Chennai, Tamil Nadu, India
17 March, 2011
15 April, 2011
27 May, 2011
01 June, 2011