SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MORPHOLINE MANNICH BASE DERIVATIVESAbstract
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gram positive strains Staphylococcus aureus and Bacillus subtilis and gram negative strains Pseudomonas aeruginosa and Escherichia coli by cup plate method. Candida albicans was used for evaluation of antifungal activity. Three dilutions of the test compounds were taken and compared against ciprofloxacin and fluconazole used as standard. The test compounds were more active towards gram positive than gram negative bacteria. Considerable antifungal activity was shown by the compounds.
H. Amin *, S. Wakode and R. K. Tonk
Centre for Medicinal Chemistry, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, Delhi, India.
01 October, 2017
16 December, 2017
25 December, 2017
01 July, 2018