SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NEWLY 1, 2, 4-TRIAZOLE DERIVATIVESAbstract
A series of 1-(2-(4H-1,2,4-triazol-4-yl)ethylamino)-3-ch-loro-4-(5-methoxy/ehthoxy-2-substituted alkyl/aryl-1H-indol-3-yl)azeti-dinones (4a-4h) and 1-(2-(4H-1,2,4-triazol-4-yl) ethylamino)-3-chloro-4-(5-methoxy/ethoxy-2-substituted alkyl/aryl-1H-indol-3-yl) thiazolidi-nones (5a-5h) have been synthesized by the reaction of 3-((2-(2-(4H-1,2,4-triazol-4-yl)ethyl)hydrazono)methyl)-5-methoxy/ethoxy-2-substi-tuted-1H-indoles (3a-3h) with chloroacetyl chloride and thioglycolic acid respectively. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, P. vulgaris, K. pneumonia and antifungal activity against A. fumigatus, C. albicans, C. albicans ATCC and C. krusei G03. The antibacterial activity of newly synthesized compounds compared with standard drug gatifloxacin and ciprofloxacin against different bacteria and antifungal activity of new compounds compared with standard drug fluconazole against different fungi. The compounds 5d, 5e, 5g, and 5h exhibited good antibacterial activity while compounds 4g, 5g, and 5h also showed notable antifungal activity. The purity of the newly synthesized compounds was checked by thin-layer chromatography (TLC) on silica gel-G coated plates using different solvent systems. The structure of all the compounds was established by the elemental (C, H, N) and spectral (IR, 1HNMR, and mass) analysis.