SYNTHESIS, CHARACTERIZATION AND EVALUATION OF SCHIFF’s BASE MUTUAL PRODRUGS OF NAPROXENAbstract
Background: A Schiff base, a pharmacologically privileged scaffold and a nitrogen analog of an aldehyde or ketone in which the C=O group is replaced by C=N-R group. Mutual prodrug is a Carrier linked prodrug consist of two pharmacologically active substances together in a single moiety. Objective: The goal of the study is to synthesize combined form of the various Schiff’s bases with Naproxen for enhanced biological and pharmacological activity. Methods: Various conventional as well as green methods are incorporated for synthesis of Schiff’s bases whereas; simple shaking method is adapted for mutual prodrug synthesis. Biological evaluation was done according to literature. Results and Conclusion: Besides Naproxen’s important pharmacological activities, it possesses severe side effects due to certain functional groups present in it. Thus, derivatization method was incorporated to shun the side effects of the drug by synthesizing its Mutual prodrugs with Schiff bases having additional antibacterial activity.
D. Gangrade * and R. Karande
Department of Pharmaceutical Chemistry, Oriental College of Pharmacy, Sanpada (W), Navi - Mumbai, Maharashtra, India.
22 March, 2018
10 June, 2018
15 June, 2018
01 November, 2018