SYNTHESIS, ELECTROCHEMICAL AND ANTIMICROBIAL ACTIVITY OF SCHIFF BASE AND ITS NICKEL (II) COMPLEXAbstract
The present study is focused on the electrochemical behavior of glycine 4-bromo acetophenonimine (GBAPI) and its Ni(II) complex. In buffer solutions (Britton-Robinson universal buffer and phosphate buffer) of pH 3 – 9 range, using cyclic voltammetric technique. GBAPI is synthesized by the condensation of 4-bromo acetophenone and glycine amino acid (1:1 molar ratio). The complex is generated by the reaction of nickel (II) acetate and GBAPI in 1: 2 molar ratio in reflexing alcohol. The process is irreversible and diffusion controlled for both GBAPI and Ni(II) complex. The effects of change in pH, solvent and sweep rate are evaluated. Kinetic parameters (charge transfer coefficient (αn), diffusion coefficient (D01/2), rate constant (k°f,h) are calculated from cyclic voltammetric measurements. These compounds are screened for their antibacterial and antifungal activities and the results are compared with those of a standard antibacterial and antifungal drug.
P. Choudhary, G. L. Kumawat, R. Sharma and S Varshney *
Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.
26 February, 2018
07 May, 2018
13 May, 2018
01 November, 2018