SYNTHESIS OF NOVEL 1, 5-DIHYDROBENZOTHIAZEPINE DERIVATIVES BY CONVENTIONAL AND MICROWAVE IRRADIATION METHODS AND THEIR PHARMACOLOGICAL ACTIVITIESAbstract
1, 5-Dihydrobenzothiazepines are synthesized by conventional and microwave assisted synthesis methods. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. The compounds have been screened for antimicrobial and cytotoxic activity. 1, 5-Dihydrobenzothiazepines are prepared by the reaction of 1, 3-diarylprop-2-enones with o-aminothiophenol. All the products were tested for purity by tlc and characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral studies.
Venkata Rao Vutla*, Rajendra Prasad Yejella and Ramarao Nadendla
Associate Professor, Department of Pharmaceutical Chemistry, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India
11 September, 2013
17 October, 2013
09 January, 2014
01 February, 2014